Endocrine Abstracts

Introduction: Fibroblast growth factor (FGF)-23 is a peptid, released from bone tissue and osteogenic cells. Phosphatonins regulate phosphate homeostasis in some phosphate wasting disorders such as X-linked hypophosphatemia, otozomal dominant hypophosphatemic rickets, and tumor-induced osteomalacia.FGF-23 is a possible phosphatonin: it regulates phosphate homeostasis by PTH independent actions.Objective: In the present study, we ai...

Background: Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by decreased responsiveness of target tissues to thyroid hormone. Two members of a Turkish family, a mother and son, had thyroid function tests suggestive of resistance to thyroid hormone (RTH).Methods: The clinical presentation was, however, different. The mother (proposita) had palpitation, weakness, tiredness, nervousness, dry mouth and was misdiagnosed as...

Objective: We aimed to investigate the expression of ret/PTC oncogene in PTC and to determine the relationship of this expression with clinical parameters and the prognosis.Materials and methods: Surgical specimens of 45 PTC and adjacent normal thyroid tissues were obtained from the files of the Department of Pathology at Istanbul Faculty of Medicine, Istanbul University. All of the patients had definite diagnosis of PTC between 1995–2003 and had ad...

Introduction: We report a case of paraganglioma of glomus caroticum with lung metastases treated with 150 mCi 131I-MIBG.Case: A 25-year-old woman was referred to our department for cachexia. She had low BMI (18) normotension, mild normochromic normocytic anemia with a mass under left mandibula. Radiologic imaging of neck revealed that 24×36×45 mm diameter mass surrounding of carotis externa and interna at the level of bifurcation. She underwent...

Background: Functional and morphological changes of endothelium are risk factors for mortality attributed to atherosclerosis. Studies investigating early atherosclerotic alterations and the effect of the treatment of acromegaly on these alterations gave conflicting results.Objective: Surrogate markers of early atheosclerotic changes, i.e. brachial artery flow-mediated dilation (FMD) and carotid artery intima-media-thickness (IMT) in active and inactive a...

Introduction: We designed a retrospective study to investigate the clinical presentation, laboratory and pathological findings of 14 patients with ACTH-independent macronodular adrenal hyperplasia.Materials and methods: Diagnose of Cushing’ s syndrome was confirmed by biochemical tests, adrenal hyperplasia was confirmed by pathological examination in all patients.Results: No supression was observed in overnight, low and high d...

Intracranial germinomas are malignant neoplasms which are supposed to arise from primitive germ cells failed to migrate to the genital crest during embryonic development. Most of them are located in the intra-suprasellar region and may cause anterior and particularly posterior pituitary hormone deficits. Early establishment of the histological diagnosis is important for optimum treatment planning and a successful outcome. Intracranial germinomas are radiosensitive and potentia...

Fine-needle aspiration biopsy (FNAB) of the thyroid gland is the most effective examination in the evaluation of thyroid nodules. To describe our experience with FNAB of the thyroid and compare the results with palpation versus ultrasonography-guided (UG) methods in an endemic goiter area in Turkey.Methods: We studied on 176 patients whom 140 were females and 36 males, submitted to FNAB of thyroid nodules at outpatient clinic of a university hospital in ...

Objectives: Detection rate of thyroid nodules is increasing with use of new imaging modalities, like 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). To avoid unnecessary operations, differentiating between benign and malignant 18F-FDG PET/CT-positive thyroid nodules is essential. Many authorities recommend fine needle aspiration biopsy (FNAB) for exclusion of malignancy in thyroid nodules. Although FNAB is a simple, easily performed proc...

Aim: FGF-21, is a member of the FGF family that is involved in biological processes such as embryonic development, cellular growth, morphogenesis, tissue repair, tumor growth and invasion, with mitogenic and cellular vital activity activity in the cytogenetic localization of 19q13.33. Breast cancer is the fatal disease most commonly seen in women and increasing in frequency and the relationship between hormones secreted from adipose tissue and some cancers has been shown in re...